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Distinctive facial features may include an abnormally round or plump (moon) face, a broad nasal bridge, widely spaced eyes (hypertelorism), crossed eyes (strabismus), downwardly slanting eyelid folds (palpebral fissures), vertical skin folds that may cover the eyes’ inner corners (epicanthal folds), low-set ears, and an abnormally small jaw (micrognathia).

Improper alignment of the upper and lower teeth (malocclusion) may also occur.

The symptoms of cri du chat syndrome vary from case to case.

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Additional symptoms affecting different organ systems of the body can also occur.

Most cases are thought arise from spontaneous (de novo) genetic errors very early in embryonic development.

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NORD gratefully acknowledges Scott Pentiuk MD, Assistant Professor of Pediatrics, Cincinnati Children's Hospital Medical Center, and Adam Mezoff, MD, Professor of Pediatrics, Cincinnati Children's Hospital Medical Center, for assistance in the preparation of this report.You can be whoever you want to be on the Night Exchange.Have hot chat with hundreds of local singles looking for adult phone chat now!You also acknowledge that any opinions, advice, statements, services, offers or other information or content made available in this chat area are those of their respective authors who are solely responsible for their content.You agree to not place postings in the Chat area that will result in a personal financial gain.Summary Cri du chat syndrome (Cd CS or 5p-) is a rare genetic disorder in which a variable portion of the short arm of chromosome 5 is missing or deleted (monosomic).