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This means there is no identifiable cause and it is called chronic idiopathic urticaria.
Recent research shows that there are auto-antibodies in about half of the patients with idiopathic urticaria and it is known as chronic autoimmune urticaria.
When the reaction is limited to small areas of the skin, it is called “urticaria.” Involvement of larger areas, suchas whole sections of a limb, is called “angioedema.” Urticaria is characterized by redness, swelling, and itching of small areas of the skin.
These patches usually grow and recede in less than a day, but may be replaced by hives in other locations.
An attack of hives is set off when such a substance, called an allergen, is ingested, inhaled, or otherwise contacted.
It interacts with immune cells called mast cells, which reside in the skin, airways, and digestive system.
In the patients who have urticaria, it is important to rule out physical urticaria.
Physical urticaria is caused by physical stimuli that cause the urticaria.
If the episode of urticaria is severe, there may be angioedema and hypotension due to a massive release of histamine into the body.
This is an emergency that requires immediate attention.
When mast cells encounter an allergen, they release histamine and other chemicals, both locally and into the bloodstream.